Uncovering Genetic and Epigenetic Programs Controlling Biological and Behavioral Flexibility
The biological flexibility needed to adapt to diverse metabolic, physiological, and behavioral challenges is central to health, disease, recovery, resilience, and aging.
What are the critical mechanisms involved?
Evolutionary changes to gene regulation shape different phenotypes in nature. How?
We are mining the genomes of different species – hibernators, megafauna, and more – to uncover gene regulatory programs for biomedical superpowers that can enhance biological flexibility and health across the lifespan. Learn more.
Understanding the mechanisms of resilience and recovery.
We have discovered novel genetic elements and gene regulatory programs for recovery in the mammalian genome and are working to understand and utilize them. Learn more.
Linking gene regulation, metabolism, neural circuits to naturalistic decision behaviors.
Behavior flexibility is key to how we adapt to different challenges across the lifespan. Using state-of-the-art Neuropixels in vivo recordings, custom deep learning models, CRISPR genetic editing, and innovative naturalistic foraging paradigms, we are uncovering the neural basis of different adaptive decision behaviors. Learn more.
Deep learning, artificial intelligence, and translation for human health.
Our lab creates massive new genomics, neural, and behavioral datasets from different species. Using these, we are pioneering the development of novel trans-species deep learning architectures and trained models that learn the codes for different genomic and behavioral adaptive responses and advancing them to improve patient care. Learn more.
Operation Warp Speed for Cancer.
Learning from evolution, we are working quickly to uncover new ways to improve cancer care using the medicines and knowledge we already have. Learn more in Dr. Gregg’s free online Uncharted Cancer masterclass here.
Finding the most important gene regulatory mechanisms and making them useful.
Gene Regulation. Metabolism. Behavior.
What People Are Saying
“This is an amazing study with many, many implications!”
— Anonymous reviewer
“This is fantastic! I love evolution papers and this is a great one.”
— Dr. Andrew Feinberg MD, MPH
“This is a thought provoking study by the Gregg group… I am excited by the implications.”
— Anonymous reviewer
“Cool stuff, and with a lucid explanation that gave me an intuition for how it worked.”
— Dr. Cori Bargman PhD
A leader at the intersection of biomedicine and A.I. technologies.
WELCOME TO UTAH
